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Senior Scientist Pharmacology

ABOUT OUR COMPANY

Assembly Biosciences (Nasdaq: ASMB) is a biotechnology company advancing two innovative platform programs: (i) HBV-cure program, which is advancing a new class of oral therapeutics for the treatment of hepatitis B virus (HBV) infection and (ii) microbiome program, which is a novel class of oral biological therapeutics, which are designed to restore health to a dysbiotic microbiome.

The Company’s microbiome program consists of a fully integrated platform that includes a robust strain identification and selection process, methods for strain isolation and growth under current Good Manufacturing Practices (cGMP) conditions, and a patent-pending delivery system, GEMICEL®, which allows for targeted oral delivery of live biologic and conventional therapies to the lower gastrointestinal (GI) tract. The lead program from this platform, ABI-M101, is in development for the treatment of C. difficile- infections (CDI). Using its microbiome platform, the Company is developing additional product candidates for multiple indications including other gastrointestinal indications, metabolic disorders, immunotherapy, and autoimmune diseases.

The Company’s HBV-cure program is aimed at increasing the current low cure rates for patients with HBV and is pursuing several drug candidates that inhibit multiple viral targets throughout the HBV lifecycle for possible use alone or in combination therapy. Assembly has discovered several novel core protein Allosteric Modulators (CpAMs), which are small molecules that directly target and allosterically modulate a number of HBV core protein functions.                                                                                                                                                                                

Job Description:

The Senior Scientist, Pharmacology will be responsible for the design, implementation and conduct of assay systems and experiments investigating the interactions between microbiota and host tissues. The right candidate will have strong expertise in host immunology (preferably mucosal immunology), experimental design and data interpretation. The role will report to the Head of Microbiome Discovery Platform - the job title and level will correspond to education level, work experience and skills of the selected candidate.

Some responsibilities include, but are not limited to: development and implementation of cell-based and other in vitro assay systems to characterize and quantify bacterial interactions with host tissues. Provide expertise in experimental design and data interpretation, with an emphasis on pharmacology and host immunity. Manage sponsored research projects with external partners in academia and industry. Work closely with other Microbiome R&D team members to integrate process development and facilitate data-sharing. Present results in visual, oral, and written forms to internal and external stakeholders.

Candidate must be able to manage junior team members and work effectively in a team environment. Good organizational skills and maintenance of good laboratory practices is key. Candidate must maintain knowledge of current techniques and any associated technological advancements. 

QUALIFICATIONS

We are looking for applicants who have an established track record of high achievement, self-motivation, professionalism, reliability, and excellent organizational skills.

  • PhD in Biology, Immunology or related fields
  • 5+ years of industry experience in biology, with an emphasis on experience with immunology, cell-culture systems and in vivo models
  • Strong skills in standard analytic techniques, including qPCR, IHC, ELISA, histology and fluorescent microscopy
  • Demonstrable track record of development and implementation of both custom and industry standard in vitro assay systems
  • Excellent analytical and written/verbal communication skills.Strong motivation, independence, and ability to work in a high-paced multidisciplinary environment. Strong attention to detail and record keeping are key.

Position Type

Full Time

Travel
This position is based in our San Francisco facility.  Some travel may be required for this position.

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